Detalhe da pesquisa
1.
Genetic variants of phospholipase C-γ2 alter the phenotype and function of microglia and confer differential risk for Alzheimer's disease.
Immunity
; 56(9): 2121-2136.e6, 2023 09 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-37659412
2.
A High-Throughput Assay to Identify Allosteric Inhibitors of the PLC-γ Isozymes Operating at Membranes.
Biochemistry
; 59(41): 4029-4038, 2020 10 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-33028071
3.
A membrane-associated, fluorogenic reporter for mammalian phospholipase C isozymes.
J Biol Chem
; 293(5): 1728-1735, 2018 02 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-29263090
4.
Small molecule inhibitors of phospholipase C from a novel high-throughput screen.
J Biol Chem
; 288(8): 5840-8, 2013 Feb 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-23297405
5.
Autoinhibition and phosphorylation-induced activation of phospholipase C-γ isozymes.
Biochemistry
; 52(28): 4810-9, 2013 Jul 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-23777354
6.
Identification of critical residues in G(alpha)13 for stimulation of p115RhoGEF activity and the structure of the G(alpha)13-p115RhoGEF regulator of G protein signaling homology (RH) domain complex.
J Biol Chem
; 286(23): 20625-36, 2011 Jun 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-21507947
7.
Dynamics of allosteric regulation of the phospholipase C-γ isozymes upon recruitment to membranes.
Elife
; 112022 06 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-35708309
8.
Regulation and physiological functions of G12/13-mediated signaling pathways.
Neurosignals
; 17(1): 55-70, 2009.
Artigo
em Inglês
| MEDLINE | ID: mdl-19212140
9.
Synthesis, characterization, and anti-melanoma activity of tetra-O-substituted analogs of nordihydroguaiaretic acid.
Bioorg Med Chem Lett
; 19(16): 4752-5, 2009 Aug 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-19615898
10.
Structural basis for the activation of PLC-γ isozymes by phosphorylation and cancer-associated mutations.
Elife
; 82019 12 31.
Artigo
em Inglês
| MEDLINE | ID: mdl-31889510
11.
Distinct regions of Galpha13 participate in its regulatory interactions with RGS homology domain-containing RhoGEFs.
Cell Signal
; 19(8): 1681-9, 2007 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-17449226
12.
Signalling mechanisms of RhoGTPase regulation by the heterotrimeric G proteins G12 and G13.
J Biochem
; 150(4): 357-69, 2011 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-21873336
13.
Gbetagamma activates GSK3 to promote LRP6-mediated beta-catenin transcriptional activity.
Sci Signal
; 3(121): ra37, 2010 May 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-20460648
14.
Activation of leukemia-associated RhoGEF by Galpha13 with significant conformational rearrangements in the interface.
J Biol Chem
; 284(8): 5000-9, 2009 Feb 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-19074425